Jameis Winston threw for 327 yards and three touchdown passes, all to Kelvin Benjamin, and the Associated Press No. 2 Seminoles held host Florida to just 193 total yards.
Florida State, which has won its first 12 games for the first time since the 1999 national championship team finished 12-0.
Benjamin had nine catches for 212 yards to go along with the three scores and the Seminoles’ defense pitched a shut out until Skyler Mornhinweg hooked up with Hunter Joyer for a five-yard touchdown early in the fourth quarter.
Florida (4-8) lost its final seven games and will miss a bowl for the first time since the 1990 team, which went 9-2 but was ineligible for the postseason.
No. 3 Ohio State 42, Michigan 41
Devin Gardner’s potential go-ahead two-point conversion pass attempt fell incomplete and the Buckeyes hung on to stay unbeaten.
Gardner, who threw for 451 yards and four touchdowns, had tossed a two-yard score to Devin Funchess with 32 seconds left that got the Wolverines (7-5) to within one point.
Ohio State (12-0) led 35-21 at the start of the fourth before Gardner threw consecutive touchdowns to Drew Dileofor 11 yards and Jake Butt for two. The visiting Buckeyes went up 42-35 on a one-yard scoring run by Carlos Hyde, who ran for 226 yards.
No. 11 Michigan State 14, Minnesota 3
Jeremy Langford ran for 135 yards and a 15-yard touchdown in the first quarter for the only points the Spartans would need. Michigan State, which leads the nation in total defense, forced three turnovers and held its fifth Big 10 opponent to single-digit points as the Spartans completed their third unbeaten regular season (1965 and 1966 were the others). MSU (11-1) will play Ohio State in the conference title game December 7.
No. 24 Duke 27, North Carolina 25
Ross Martin kicked a 37-yard field goal with 2:22 left in the fourth quarter to lift the Blue Devils to their eighth consecutive victory. Duke (10-2, 6-2 Atlantic Coast Conference) wrapped up the ACC’s Coastal Division title and will play Florida State in the ACC championship game. Anthony Boone threw for 274 yards and two touchdowns — both to Jamison Crowder — and Devon Edwards, an Alcovy High School graduate, had a 99-yard kick off return for a touchdown just before halftime.
North Carolina (6-6, 4-4 ACC) had taken a 25-24 lead on Thomas Moore’s 37-yard field goal with 7:03 to play before the visiting Blue Devils drove 66 yards in a little less than five minutes for Martin’s game-winner.